AHKCU 0.5G + Micro needling bottle

What is AHK-Cu?

AHK-Cu (L-alanyl-L-histidyl-L-lysine-Cu²⁺) is a copper-binding peptide specifically researched for its effects on hair growth. It works at a cellular level to create a more favorable environment for hair follicles.

Key mechanisms of action:

• Stimulates dermal papilla cell proliferation: Dermal papilla cells are specialized fibroblasts that play a critical role in hair follicle morphogenesis and growth . AHK-Cu significantly stimulates their proliferation .

• Prevents follicle cell apoptosis: AHK-Cu reduces apoptosis (programmed cell death) in dermal papilla cells. It achieves this by increasing the Bcl-2/Bax ratio and reducing the levels of cleaved caspase-3 and PARP, key markers of cell death .

• Promotes hair follicle elongation: Studies have shown that AHK-Cu directly stimulates the elongation of human hair follicles in ex vivo models .

The Role of Microneedling

Microneedling is a procedure that uses fine needles to create controlled micro-injuries and micro-channels in the scalp . This serves two main purposes in hair restoration:

1. Enhanced Delivery: The micro-channels created by the needles temporarily bypass the skin’s barrier, allowing topical solutions like AHK-Cu to penetrate far more deeply and be delivered directly to the hair follicle .

2. Stimulation of Regeneration: The micro-injuries themselves trigger the body’s natural wound-healing response, increasing blood flow and releasing growth factors that can stimulate weakened or inactive hair follicles .

Combining AHK-Cu with Microneedling

The combination is a logical synergy: microneedling creates the “pathway,” and AHK-Cu provides the “signal” for follicle regeneration.

Critical Safety Note on Dosage:
A crucial consideration when combining these two is the concentration of AHK-Cu.

• For application on intact skin, a standard concentration of 1% to 2.5% is common .

• However, microneedling can increase absorption by 100 times or more . Therefore, if applying AHK-Cu immediately after microneedling, it is vital to significantly reduce the concentration to avoid skin irritation and potential copper overload .

A typical approach mirrors protocols used for GHK-Cu, a related copper peptide: use a very low concentration (e.g., 0.05%) for application post-needling .

WHAT COMES IN THE KIT:

1x RAW AHK-CU 0.5G

2. MICRO NEDDLING BOTTLE

3. 20 ml of liquid 

Typical Protocol Expectations: